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产品属性：
产品名称 | Ac-DEVD-CHO (trifluoroacetate salt) |
规格 | 500µg、1mg、5mg、10mg |
货号 | EY-01Y10327 |
Cas No.: N/A
别名: N/A
化学名: N/A
分子式: C20H30N4O11•XCF3COOH
分子量: 502.5
溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively).1,2 Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).1 Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK , are irreversible.1 Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.31.Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49)32608-32613(1998)
2.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9677-9682(1997)
3.Nicholson, D.W., Ali, A., Thornberry, N.A., et al.Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisNature37637-43(1995)
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