上海一研生物科技有限公司

产品属性：

Cas No.: 528-71-2

别名: N/A

化学名: N/A

分子式: C12H8N2O

分子量: 196.2

溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

1-Hydroxyphenazine is a phenazine pigment and virulence factor produced by P. aeruginosa.1,2 It increases production of reactive oxygen species (ROS) in RAW 264.7 cells in a concentration-dependent manner.2 1-Hydroxyphenazine (≥1.55 and ≥3.12 μM) increases release of elastase and myeloperoxidase (MPO), respectively, by human neutrophils activated with N-formyl-L-methionyl-L-leucyl-L-phenylalanine and cytochalasin B .1 It reduces ciliary beat frequency in isolated guinea pig tracheal rings, resulting in ciliary dyskinesia by 1 hour when used at concentrations of 10, 50, and 100 μM and ciliary stasis by 5 hours at 50 and 100 μM.3 1-Hydroxyphenazine reduces tracheal mucus velocity in anesthetized guinea pigs when administered as a 100 or 200 ng bolus dose. It is also active against the plant pathogenic fungi F. graminearum, P. grisea, A. solani, F. oxysporium, and S. sclerotiorum (MICs = 2-50 μg/ml).41.Ramafi, G., Anderson, R., Theron, A., et al.Exposure of N-formyl-L-methionyl-L-leucyl-L-phenylalanine-activated human neutrophils to the Pseudomonas aeruginosa-derived pigment 1-hydroxyphenazine is associated with impaired calcium efflux and potentiation of primary granule enzyme releaseInfect. Immun.67(10)5157-5162(1999)

2.Sinha, S., Shen, X., Gallazzi, F., et al.Generation of reactive oxygen species mediated by 1?hydroxyphenazine, a virulence factor of Pseudomonas aeruginosaChem. Res. Toxicol.28(2)175-181(2015)

3.Munro, N.C., Barker, A., Rutman, A., et al.Effect of pyocyanin and 1-hydroxyphenazine on in vivo tracheal mucus velocityJ. Appl. Physiol.67(1)316-323(1985)

4.Luo, Q., Hu, H., Peng, H., et al.Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510Chin. J. Chem. Eng.23(4)699-703(2015)
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