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产品属性：
产品名称 | 7-hydroxy Methotrexate |
规格 | 500 µg、1 mg、5 mg、10 mg |
货号 | EY-01Y10484 |
Cas No.: 5939-37-7
别名: N/A
化学名: N/A
分子式: C20H22N8O6
分子量: 470.4
溶解度: DMSO: slightly soluble,Ethanol: slightly soluble
储存条件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
7-hydroxy Methotrexate (7-hydroxy MTX) is the major metabolite of the folic acid derivative MTX .1 It is formed by the 7-oxidation of MTX by hepatic aldehyde oxidases. Unlike MTX, 7-hydroxy MTX does not inhibit thymidylate synthase in isolated human acute myeloid and acute lymphoblastic leukemia cells.2 7-hydroxy MTX has a maximum tolerated dose of 0.1 g/kg, which is 30- to 50-fold lower than MTX, in rats.3 Serum levels of 7-hydroxy MTX have been used as a marker of MTX toxicity during chemotherapy.4,51.Johns, D.G., Iannotti, A.T., Sartorelli, A.C., et al.The relative toxicites of methotrexate and aminopterinBiochem. Pharmacol.15(5)555-561(1966)
2.Lingg, R.M., Hempel, G., Rots, M.G., et al.Effects and interaction of 7-hydroxy methotrexate and methotrexate in leukaemic cells ex vivo measured by the thymidylate synthase inhibition assayCancer Chemother. Pharmacol.56(3)322-327(2005)
3.FuskevÅg, O.M., Kristiansen, C., Lindal, S., et al.Maximum tolerated doses of methotrexate and 7-hydroxy-methotrexate in a model of acute toxicity in ratsCancer Chemother. Pharmacol.46(1)69-73(2000)
4.Schofield, R.C., Ramanathan, L.V., Murata, K., et al.Development of an assay for methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum by LC-MS/MSMethods in Molecular Biology213-222(2016)
5.Klapkova, E., Kukacka, J., Kotaska, K., et al.The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determinationClin. Lab.57(7-8)599-606(2011)
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