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产品属性：
产品名称 | 4-CPPC |
规格 | 500 μg、1 mg、5 mg、10 mg |
货号 | EY-01Y10485 |
Cas No.: 29553-70-6
别名: N/A
化学名: N/A
分子式: C14H9NO6
分子量: 287.2
溶解度: DMSO: soluble
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50 = 27 µM).1 It is selective for MIF-2 over MIF-1 (IC50 = 450 µM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 µM. 4-CPPC (5, 10, and 25 µM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts. 1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)
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