上海一研生物科技有限公司

产品属性：

Cas No.: 19716-61-1

别名: N/A

化学名: N/A

分子式: C19H13NO5

分子量: 335.3

溶解度: Chloroform: soluble

储存条件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

8-Oxycoptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has anticancer and gastroprotective activities.1,2,3 It is an active metabolite of coptisine formed by gut microbiota.1 8-Oxycoptisine is cytotoxic against NCI-N87 gastric, but not Caco-2 colon, cancer cells (IC50s = 20.31 and >100 µM, respectively).2 It reverses resistance to paclitaxel in non-multidrug-resistant SKOV3 cells, as well as in HCT-15 cells, which endogenously express high levels of P-glycoprotein (P-gp), with EC50 values of 0.3 and 0.5 ng/ml, respectively.3 It reduces colonic shortening and inflammatory cell infiltration in a mouse model of ulcerative colitis induced by dextran sulfate when administered at doses of 50 or 100 mg/kg.11.Ai, G., Huang, Z., Cheng, J., et al.Gut microbiota-mediated transformation of coptisine Into a novel metabolite 8-oxocoptisine: Insight into its superior anti-colitis effectFront. Pharmacol.1212:639020(2021)

2.Qian, P., and Yang, X.-W.Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cellsFitoterapia9374-80(2014)

3.Min, Y.D., Yang, M.C.M., Lee, K.H., et al.Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica MakinoArch. Pharm. Res.29(9)757-761(2006)
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