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产品属性：
产品名称 | (5Z,2E)-CU-3 |
规格 | 10mM*1 mL in DMSO、5mg、10mg、25mg、50mg、100mg |
货号 | EY-01Y10465 |
Cas No.: 1815598-71-0
别名: N/A
化学名: N/A
分子式: C16H12N2O4S3
分子量: 392.47
溶解度: DMSO: 20 mg/mL (50.96 mM; ultrasonic and warming and heat to 60°C); H2O: < 0.1 mg/mL (insoluble)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.
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