上海一研生物科技有限公司

产品属性：

Cas No.: 1287076-43-0

别名: N/A

化学名: N/A

分子式: C12H8D7N3O2S

分子量: 272.4

溶解度: DMSO: slightly soluble,Methanol: slightly soluble

储存条件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms.1 It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (0.05% in the diet) protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM), halts the cell cycle at the G2/M phase, and induces apoptosis. In an HT-29 mouse xenograft model, it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally.2 Albendazole inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50s = 6.9 and 0.21 µM, respectively).3 Formulations containing albendazole have been used in the treatment of tapeworm infections and in a variety of nematode infections in livestock and pets.1.Theodorides, V.J., Gyurik, R.J., Kingsbury, W.D., et al.Anthelmintic activity of albendazole against liver flukes, tapeworms, lung and gastrointestinal roundwormsExperientia32(6)702-703(1976)

2.Pourgholami, M.H., Akhter, J., Wang, L., et al.Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: In vitro and in a xenograft model of peritoneal carcinomatosisCancer Chemother. Pharmacol.55(5)425-432(2005)

3.Lacey, E.Mode of action of benzimidazolesParasitol. Today6(4)112-115(1990)
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