上海一研生物科技有限公司

产品属性：

Cas No.: 1220973-37-4

别名: N/A

化学名: N/A

分子式: C22H22ClN3O5

分子量: 443.9

溶解度: DMF: 5 mg/ml,DMSO: 20 mg/ml

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

AKP-11 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) with an EC50 value of 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing the human receptor.1 It decreases surface expression of S1P1 and increases phosphorylation of Akt and ERK in CHO cells expressing S1P1-HA when used at a concentration of 100 nM.2 AKP-11 (1.3 and 3 mg/kg) reduces protein levels of IFN-γ and IL-17 in spinal cord tissue and decreases disease severity in a rat model of experimental autoimmune encephalomyelitis (EAE). It decreases peripheral counts of total lymphocytes and total, CD4+, CD8+, and CD26L+ T cells in an EAE rat model, as well as in health control animals, when administered at a dose of 1.3 mg/kg.|2. Samuvel, D.J., Saxena, N., Dhindsa, J.S., et al. AKP-11 - A novel S1P1 agonist with favorable safety profile attenuates experimental autoimmune encephalomyelitis in rat model of multiple sclerosis. PLoS One 10(10):e0141781, (2015).
特别提醒公司产品仅供科研使用