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产品属性：
产品名称 | Acetyl-L-carnitine-d3 (chloride) |
规格 | 5 mg、10 mg、25 mg、50 mg |
货号 | EY-01Y11284 |
Cas No.: 362049-62-5
别名: N/A
化学名: N/A
分子式: C9H15D3NO4.Cl
分子量: 242.7
溶解度: Methanol: slightly soluble,Water: soluble
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Acetyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of L-acetylcarnitine by GC- or LC-MS. Acetyl-L-carnitine is an acetylated form of the essential mitochondrial metabolite L-carnitine that is catabolized by plasma esterases into carnitine.1,2,3 Acetyl-L-carnitine facilitates the uptake of acetyl-CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. In vivo, acetyl-L-carnitine (100 mg/kg) increases mGlu2/3 receptor protein levels and mechanical pain thresholds in a mouse model of chronic inflammatory pain induced by complete Freund's adjuvant.41.Vaz, F.M., and Wanders, R.J.A.Carnitine biosynthesis in mammalsBiochem. J.361(Pt 3)417-429(2002)
2.Fu, L., Huang, M., and Chen, S.Primary carnitine deficiency and cardiomyopathyKorean. Circ. J.43(12)785-792(2013)
3.Stieger, B., O'Neill, B., and KrÄhenbÜhl, S.Characterization of L-carnitine transport by rat kidney brush-border-membrane vesiclesBiochemistry Journal309(Pt 2)643-647(1995)
4.Notartomaso, S., Mascio, G., Bernabucci, M., et al.Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic painMol. Pain13:1744806917697009(2017)
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