上海一研生物科技有限公司

产品属性：

Cas No.: 330796-62-8

别名: N/A

化学名: N/A

分子式: C20H24D8O3

分子量: 328.5

溶解度: 0.1 M Na2CO3: 2 mg/ml,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS pH 7.2: 0.8 mg/ml

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

5(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 5(S)-HETE by GC- or LC-mass spectrometry (MS). 5(S)-HETE is produced by the action of 5-lipoxygenase on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE has proliferative and chemotactic effects on granulocytes.1 When further metabolized to the 5-oxoETE, it is a more potent eosinophil chemoattractant than leukotriene B4.2,31.Schwenk, U., and SchrÖder, J.M.5-Oxo-eicosanoids are potent eosinophil chemotactic factors. Functional characterization and structural requirementsJ. Biol. Chem.270(25)15029-15036(1994)

2.Powell, W.S., Gravelle, F., and Gravel, S.Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytesJ. Biol. Chem.267(27)19233-19241(1992)

3.Dodge, W., and Thomas, M.The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chickBiochem. Biophys. Res. Commun.131(2)731-735(1985)
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