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产品属性：
产品名称 | 4-Ethynyl-L-phenylalanine hydrochloride |
规格 | 10mM*1 mL in DMSO、50mg |
货号 | EY-01Y11680 |
Cas No.: 188640-63-3
别名: N/A
化学名: N/A
分子式: C11H12ClNO2
分子量: 225.67
溶解度: Methanol: 125 mg/mL (553.91 mM); DMSO: 100 mg/mL (443.12 mM); H2O: < 0.1 mg/mL (insoluble)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
4-Ethynyl-L-phenylalanine hydrochloride is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine hydrochloride is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1].4-Ethynyl-L-phenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].4-Ethynyl-L-phenylalanine hydrochloride is not inhibiting the aromatic amino acid decarboxylase[1].4-Ethynyl-L-phenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors[1].Animal Model:Male Sprague-Dawley rats (200 g)[1][1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.
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