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产品属性：
产品名称 | Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt) |
规格 | 500 μg、1 mg |
货号 | EY-01Y11864 |
Cas No.: N/A
别名: N/A
化学名: N/A
分子式: C194H295N53O58S.XCF3COOH
分子量: 4329.8
溶解度: DMSO: 2 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Amyloid-β (1-40) (Aβ40) peptide is a 40-residue protein fragment of Aβ42 , a neurotoxic peptide found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2 Aβ40 is more abundant, less neurotoxic, and does not form oligomers as easily as Aβ42.3,4 Aβ40 inhibits in vitro fibrillization of Aβ42 in a concentration-dependent manner.5 It also inhibits Aβ42-induced cell death in cultured rat embryonic cortical neurons in a concentration-dependent manner. Aβ40 prevents Aβ42-induced increases in the number of GFAP-positive astrocytes in rat entorhinal cortex.1.Wolfe, M.S.Therapeutic strategies for Alzheimer's diseaseNat. Rev. Drug Discov.1(11)859-866(2002)
2.Iwatsubo, T., Odaka, A., Suzuki, N., et al.Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)Neuron13(1)45-53(1994)
3.Bitan, G., Kirkitadze, M.D., Lomakin, A., et al.Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathwaysProc. Natl. Acad. Sci. USA100(1)330-335(2003)
4.Murphy, M.P., and LeVinne, H., IIIAlzheimer's disease and the β-amyloid peptideJ. Alzheim. Dis.19(1)311(2010)
5.Zou, K., Kim, D., Kakio, A., et al.Amyloid β-protein (Aβ)1-40 protects neurons from damage induced by Aβ1-42 in culture and in rat brainJ. Neurochem.87(3)609-619(2003)
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