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产品属性：
产品名称 | HSP27 inhibitor J2 |
规格 | 1mg、5mg、10mg、25mg、50mg、100mg |
货号 | EY-01Y11835 |
Cas No.: 2133499-85-9
别名: N/A
化学名: N/A
分子式: C13H12O4S
分子量: 264.3
溶解度: DMSO: 25 mg/mL (94.59 mM)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].[1]. Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900.
[2]. Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.
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