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产品属性：
产品名称 | Peptide 74 |
规格 | 5 mg、10 mg、25 mg |
货号 | EY-01Y12019 |
Cas No.: 132116-39-3
别名: N/A
化学名: N/A
分子式: C62H107N23O20S2
分子量: 1558.79
溶解度: H2O : 100 mg/mL (64.15 mM; Need ultrasonic)
储存条件: -20°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro[1].Peptide 74 (30 μM) reduces both A2058 and HT 1080 tumor cell invasion by 60-80%[1]. Peptide 74 (30 μM) shows no cytotoxic action and does not inhibit chemotaxis or affect HT1080 and A2058 human tumor cells number[1].[1]. A Melchiori, et al. Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment. Cancer Res. 1992 Apr 15;52(8):2353-6. [2]. P P Lee, et al. Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development. J Cell Physiol. 2001 Jul;188(1):75-88.
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