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产品属性：
产品名称 | Amyloid-β (17-42) Peptide (human) (trifluoroacetate salt) |
规格 | 500μg |
货号 | EY-01Y12059 |
Cas No.: N/A
别名: N/A
化学名: N/A
分子式: C119H194N28O33S•XCF3COOH
分子量: 2577.1
溶解度: Formic Acid: 1 mg/ml
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Amyloid-β (Aβ) (17-42) is a 26-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases. It has been found in postmortem cerebral cortex from patients with Alzheimer's disease that have diffuse amyloid plaques and in cerebellar preamyloid lesions in patients with Down's syndrome. In vitro, Aβ (17-42) forms amorphous aggregates that bind less thioflavin T than Aβ (1-40) and Aβ (1-42) . It is cytotoxic to SH-SY5Y and IMR-32 cells in a concentration-dependent manner and induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells when used at a concentration of 20 μM.
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