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产品属性：
产品名称 | Fmoc-Ala-Glu-Asn-Lys-NH2 |
规格 | 5 mg、10 mg |
货号 | EY-01Y12144 |
Cas No.: 220701-06-4
别名: N/A
化学名: N/A
分子式: C33H43N7O9
分子量: 681.74
溶解度: DMSO: 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)
储存条件: -20°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.
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