JMV 449 acetate
JMV 449 acetate
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产品属性:


产品名称

JMV 449 acetate

规格

5 mg、10 mg

货号

EY-01Y12231

Cas No.: N/A

别名: N/A

化学名: N/A

分子式: C40H70N8O9
GC61800.png
分子量: 807.03

溶解度: H2O: 100 mg/mL (123.91 mM)

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述:


JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect[2].Animal Model:Male Swiss albino mice[1][1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198.

[2]. Dubuc I, et al. JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.
特别提醒公司产品仅供科研使用


英文名称
JMV 449 acetate
货号
EY-01Y12231
含量
>99.00%
规格
5 mg、10 mg
品牌
上海一研
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