上海一研生物科技有限公司

产品属性：

Cas No.: 141172-08-9

别名: N/A

化学名: N/A

分子式: C18H20O3

分子量: 284.35

溶解度: Soluble in DMSO

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin[1].Tubulin[1].SS28 (0-20 μM) induces cytotoxicity in different cancer cell lines[1].SS28 treatment (5 μM for A549 and 2 μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation[1].Cell Proliferation Assay[1]    Cell Line:CEM, Reh, Nalm6, SUDHL8, Molt4, A549, HeLa 293T cells.SS28 (15 mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation[1].Animal Model:BALB/c mice using EAC cells[1].[1]. Thomas E, et al. A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells. Sci Rep. 2016 Oct 17;6:34653.
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