- 产品详情
- 产品参数
- 产品评论
产品属性：
产品名称 | (±)-Thalidomide-d4 |
规格 | 1mg、5mg |
货号 | EY-01Y12372 |
Cas No.: 1219177-18-0
别名: N/A
化学名: N/A
分子式: C13H6D4N2O4
分子量: 262.3
溶解度: DMF: 12 mg/ml,DMSO: 12 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.11 mg/ml
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
(±)-Thalidomide-d4 is intended for use as an internal standard for the quantification of (±)-thalidomide by GC- or LC-MS. (±)-Thalidomide is an immunomodulatory and antiproliferative compound that interacts directly with the protein CRBN (IC50 = 8.5 nM), a ubiquitously-expressed E3 ligase, and CRBN-DDB1 complexes.1,2|1. Ito, T., Ando, H., Suzuki, T., et al. Identification of a primary target of thalidomide teratogenicity. Science 327(5971), 1345-1350 (2010).|2. Lopez-Girona, A., Mendy, D., Miller, K., et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26(11), 2326-2335 (2012).
特别提醒公司产品仅供科研使用
