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产品属性：
产品名称 | 653-47 hydrochloride |
规格 | 10mM*1 mL in DMSO、5 mg、10 mg、25 mg、50 mg、100 mg |
货号 | EY-01Y12552 |
Cas No.: 1224567-46-7
别名: N/A
化学名: N/A
分子式: C20H20Cl2N2O3
分子量: 407.29
溶解度: DMSO : 250 mg/mL (613.81 mM; Need ultrasonic)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
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