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产品属性：
产品名称 | (R)-BAY-598 |
规格 | 500μg、1mg、5mg、10mg |
货号 | EY-01Y12672 |
Cas No.: 1906920-28-2
别名: N/A
化学名: N/A
分子式: C22H20Cl2F2N6O3
分子量: 525.3
溶解度: Soluble in DMSO
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
(R)-BAY-598 is an inhibitor of the lysine N-methyltransferase SMYD2 (IC50 = 1.7 μM) and a less active enantiomer of (S)-BAY-598 .1 It is selective for SMYD2 over proteinase-activated receptor 1 (PAR1; IC50 = >30 μM).|1. Eggert, E., Hillig, R.C., Koehr, S., et al. Discovery and characterization of a highly potent and selective aminopyrazoline-based in vivo probe (BAY-598) for the protein lysine methyltransferase SMYD2. J. Med. Chem. 59(10), 4578-4600 (2016).
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