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产品属性：
产品名称 | 5-Iodo-indirubin-3'-monoxime |
规格 | 250mg、500mg |
货号 | EY-01Y13100 |
Cas No.: 331467-03-9
别名: N/A
化学名: N/A
分子式: C16H10IN3O2
分子量: 403.17
溶解度: DMSO: 67.5 mg/mL (167.42 mM)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].
GSK-3β|9 nM (IC50)|Cdk5/p25|20 nM (IC50)|Cdk1/cyclin B|25 nM (IC50)
[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors• J Biol Chem. 2001 Jan 5;276(1):251-60.
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