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产品属性：
产品名称 | 9-Methoxyellipticine |
规格 | 1mg、5mg |
货号 | EY-01Y13091 |
Cas No.: 10371-86-5
别名: N/A
化学名: N/A
分子式: C18H16N2O
分子量: 276.3
溶解度:
储存条件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine that has been found in O. maculata and has anticancer activity.1,2 It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V; IC50s = 0.8 and 0.6 µM, respectively).2,3 9-Methoxyellipticine inhibits proliferation of Ba/F3 cells in the presence of the c-Kit ligand SCF and Ba/F3 cells expressing c-KitD816V (IC50s = 0.5 and 0.3 µM, respectively).2 It also increases survival in a variety of rodent tumor models.11.Svoboda, G.H., Poore, G.A., and Montfort, M.L.Alkaloids of Ochrosia maculata Jacq. (Ochrosia borbonica Gmel.). Isolation of the alkaloids and study of the antitumor properties of 9-methoxyellipticineJ. Pharm. Sci.57(10)1720-1725(1968)
2.VendÔme, J., Letard, S., Martin, F., et al.Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinasesJ. Med. Chem.48(20)6194-6201(2005)
3.Festy, B., Poisson, J., and Paoletti, C.A new DNA intercalating drug: Methoxy-9-ellipticineFEBS Lett.17(2)321-323(1971)
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