上海一研生物科技有限公司

产品属性：

Cas No.: 1225580-94-8

别名: N/A

化学名: N/A

分子式: C5H7D3NO4S.1/2Ca

分子量: 203.3

溶解度: Water: slightly soluble

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

Acamprosate-d3 is intended for use as an internal standard for the quantification of acamprosate by GC- or LC-MS. Acamprosate is an acetylated derivative of the GABA analog homotaurine .1 Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 µM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release.2,3,4 It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors.4 Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline . Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.1.Boismare, F., Daoust, M., Moore, N., et al.A homotaurine derivative reduces the voluntary intake of ethanol by rats: Are cerebral GABA receptors involved•Pharmacol. Biochem. Behav.21(5)787-789(1984)

2.Reilly, M.T., Lobo, I.A., McCracken, L.M., et al.Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytesAlcohol. Clin. Exp. Res.32(2)188-196(2008)

3.Berton, F., Francesconi, W.G., Madamba, S.G., et al.Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABAB receptors in nucleus accumbens neuronsAlcohol Clin. Exp. Res.22(1)183-191(1998)

4.Tomek, S.E., Lacrosse, A.L., Nemirovsky, N.E., et al.NMDA receptor modulators in the treatment of drug addictionPharmaceuticals (Basel)6(2)251-268(2013)
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