- 产品详情
- 产品参数
- 产品评论
产品属性：
产品名称 | 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α |
规格 | 1 mg、5 mg、10 mg |
货号 | EY-01Y13576 |
Cas No.: 294856-01-2
别名: N/A
化学名: N/A
分子式: C24H33O5F3
分子量: 458.5
溶解度: DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3 Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.4 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α would act very much like the free acid of latanoprost.1.Woodward, D.F., Krauss, A.H.P., Chen, J., et al.The pharmacology of Bimatoprost (LumiganTM)Survey of Ophthalmology45S337-S345(2001)
2.Stjernschantz, J.W.From PGF2α-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lectureInvestigative Ophthalmology & Visual Science42(6)1134-1145(2001)
3.Sorbera, L.A., and CastaÑer, J.TravoprostDrugs Future25(1)41-45(2000)
4.Resul, B., Stjernschantz, J., No, K., et al.Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agentsJournal of Medicinal Chemistry36243-248(1993)
特别提醒公司产品仅供科研使用
