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产品属性：
产品名称 | AA92593 |
规格 | 10mM*1 mL in DMSO、5 mg、10 mg、25 mg、50 mg、100 mg |
货号 | EY-01Y13579 |
Cas No.: 457961-34-1
别名: N/A
化学名: N/A
分子式: C13H19NO3S
分子量: 269.36
溶解度: DMSO : 250 mg/mL (928.13 mM)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
AA92593 is a selective and competitive OPN4 (melanopsin) antagonist[1][2].AA92593 is a competitive melanopsin antagonist, its presence in the retinal-binding pocket of melanopsin leads to the displacement of retinal, which could trigger a downstream signaling that would ultimately result in Per1 increased expression[1].AA92593 is shown to be specific because it competes with retinaldehyde for the melanopsin retinal binding site which is very distinct from other opsins[1].Inhibition of melanopsin activity with AA92593 increases a-MSH expression and induces melanin dispersion in the melanophores, which darkens the embryo[3].AA92593 exhibits an IC50 of 665 nM in CHOOpn4 cells[4].AA92593 is able to decrease IOP in rabbits living under normal light condition[2].AA92593 produces an increment in melatonin levels resulting in a drop of IOP[2].
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