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产品属性：
产品名称 | Acepromazine (maleate) |
规格 | 10mg、50mg、100mg、250mg |
货号 | EY-01Y13581 |
Cas No.: 3598-37-6
别名: N/A
化学名: N/A
分子式: C19H22N2OS.C4H4O4
分子量: 442.5
溶解度: DMF: 1mg/mL,DMSO: 3mg/mL,Ethanol: 2mg/mL,PBS (pH 7.2): 2mg/mL
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Acepromazine is a phenothiazine antipsychotic, analog of chlorpromazine , and a dopamine receptor antagonist.1 It also binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits contractions of guinea pig ileum induced by acetylcholine .2 Acepromazine inhibits morphine-induced vomiting in dogs.3 It also inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED50s = 0.98, 3.1, and 17 mg/kg, respectively).4 Formulations containing acepromazine have been used as tranquilizers and anesthetics premedicant in small and large animal veterinary care.References1. Monteiro, E.R., Teixeira Neto, F.J., Castro, V.B., et al. Effects of acepromazine on the cardiovascular actions of dopamine in anesthetized dogs. Vet. Anaesth. Analg. 34(5), 312-321 (2007).2. Fjalland, B., Christensen, A.V., and Hyttel, J. Peripheral and central muscarinic receptor affinity of psychotropic drugs. Naunyn. Schmiedebergs. Arch. Pharmacol. 301(1), 5-9 (1977).3. Koh, R.B., Isaza, N., Xie, H., et al. Effects of maropitant, acepromazine, and electroacupuncture on vomiting associated with administration of morphine in dogs. J. Am. Vet. Med. Assoc. 244(7), 820-829 (2014).4. J., A. Pharmacological specificity of conditioned avoidance response inhibition in rats: Inhibition by neuroleptics and correlation to dopamine receptor blockade. Acta. Pharmacol. Toxicol. (Copenh). 51(4), 321-329 (1982).
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