- 产品详情
- 产品参数
- 产品评论
产品属性：
产品名称 | AAT-008 |
规格 | 1mg、5mg、10mg、25mg |
货号 | EY-01Y13862 |
Cas No.: 847727-81-5
别名: N/A
化学名: N/A
分子式: C21H16ClFN2O4
分子量: 414.8
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 0.5 mg/ml
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
AAT-008 is an orally bioavailable and potent antagonist of the prostaglandin E2 (PGE2) receptor subtype 4 (EP4; IC50 = 16.3 nM in a human EP4 functional assay). It is selective for EP4 with IC50 values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human recombinant EP4, EP2, EP1, and EP3, respectively. AAT-008 has potent binding affinity for human, rat, and dog EP4 (Kis = 0.97, 6.1, and 38 nM, respectively) and suppresses PGE2-induced elevation of intracellular cAMP with an antagonistic potency (pA2) of 1.1 nM in vitro. Oral administration of AAT-008 reduces carrageenan-induced mechanical hyperalgesia in rats in a dose-dependent manner.
特别提醒公司产品仅供科研使用
