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产品属性：
产品名称 | 3-Hydroxyisobutyrate (sodium salt) |
规格 | 250mg、1g |
货号 | EY-01Y13944 |
Cas No.: 1219589-99-7
别名: 3-HIB
化学名: 3-hydroxy-2-methyl-propanoic acid, monosodium salt
分子式: C4H7O3•Na
分子量: 126.1
溶解度: 5 mg/ml in Ethanol
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
3-Hydroxyisobutyrate (3-HIB) is an intermediate in the metabolism of the branched-chain amino acid valine that is secreted by skeletal muscle. [1] [2] It dose-dependently increases fatty acid uptake by human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 0.1 to 100 mM. [3] 3-HIB also increases fatty acid uptake and lipid accumulation in mouse skeletal muscle when administered in drinking water. The levels of 3-HIB in muscle are increased in db/db diabetic mice and in humans with diabetes. Human plasma levels are increased in obesity and correlate with a future risk of type 2 diabetes.[3] In addition, human serum levels of 3-HIB decrease by 2.5-fold immediately following an exercise regimen of 2.5 hours of running for three days. [1]
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