上海一研生物科技有限公司

产品属性：

Cas No.: 159490-55-8

别名: N/A

化学名: N/A

分子式: C16H11D3O3

分子量: 257.3

溶解度: DMSO: soluble,Methanol: soluble

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

(±)-Ketoprofen-d3 is intended for use as an internal standard for the quantification of (±)-ketoprofen by GC- or LC-MS. (±)-Ketoprofen is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID).1 It inhibits human recombinant COX-1 and COX-2 with IC50 values of 0.5 and 2.33 μM, respectively. In vivo, (±)-ketoprofen reduces carrageenan-induced paw edema and increases latency to paw withdrawal in the hot plate test in rats when administered using a sustained-release implant.2 Formulations containing (±)-ketoprofen have been used to treat pain and inflammation in osteoarthritis.References1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys. Acta. 1209(1), 130-139 (1994).2. Zhang, J., Xu, X., Zhu, L., et al. Preparation and pre-clinical characterization of sustained release ketoprofen implants for the management of pain and inflammation in osteoarthritis. Trop. J. Pharm. Res. 17(4), 577-582 (2018).
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