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产品属性：
产品名称 | (R)-ADX-47273 |
规格 | Free Sample (0.1-0.5 mg)、5mg、10mg、50mg、100mg、200mg |
货号 | EY-01Y14161 |
Cas No.: 851881-59-9
别名: N/A
化学名: N/A
分子式: C20H17F2N3O2
分子量: 369.36
溶解度: Soluble in DMSO
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
mGluR5|168 nM (EC50)
(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM[1].[1]. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11.
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