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产品属性：
产品名称 | 10β,17β-dihydroxyestra-1,4-dien-3-one |
规格 | 10mM*1mL in DMSO、1mg、5mg、10mg、25mg、50mg、100mg、200mg |
货号 | EY-01Y14226 |
Cas No.: 549-02-0
别名: N/A
化学名: N/A
分子式: C18H24O3
分子量: 288.38
溶解度: DMSO: 250 mg/mL (866.91 mM)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1].[1]. Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery. Sci Rep. 2016 Aug 1;6:30721.
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