上海一研生物科技有限公司

产品属性：

Cas No.: 1217449-45-0

别名: N/A

化学名: N/A

分子式: [13C]17H12O6

分子量: 329.1

溶解度: Acetonitrile: soluble

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

Aflatoxin B1-13C17 (AFB1-13C17) is intended for use as an internal standard for the quantification of AFB1 by GC- or LC-MS. AFB1 is a genotoxic mycotoxin that has been found in Aspergillus.1,2 It induces the formation of DNA adducts in rat liver microsomes.1 AFB1 induces transversion of guanine to thymine at codon 29 of the p53 tumor suppressor gene, a mutation commonly seen in hepatocellular carcinoma patients living in regions with high levels of aflatoxin contamination, in HepG2 cells.2 In vivo, AFB1 (50 and 100 µg/kg) induces hepatocellular carcinoma tumor formation in rats.3 1.Essigmann, J.M., Croy, R.G., Nadzan, A.M., et al.Structural identification of the major DNA adduct formed by aflatoxin B1 in vitroProc. Natl. Acad. Sci. USA74(5)1870-1874(1977)

2.Aguilar, F., Hussain, S.P., and Cerutti, P.Aflatoxin B1 induces the transversion of G -> T in codon 249 of the p53 tumor suppressor gene in human hepatocytesProc. Natl. Acad. Sci. USA90(18)8586-8590(1993)

3.Wogan, G.N., Paglialunga, S., and Newberne, P.M.Carcinogenic effects of low dietary levels of aflatoxin B1 in ratsFd. Cosmet. Toxicol.12(5-6)681-685(1974)
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