- 产品详情
- 产品参数
- 产品评论
产品属性：
产品名称 | (S)-Mapracorat |
规格 | 10mM*1mL in DMSO、5mg、10mg、50mg、100mg |
货号 | EY-01Y14558 |
Cas No.: 887375-15-7
别名: N/A
化学名: N/A
分子式: C25H26F4N2O2
分子量: 462.48
溶解度: DMSO: ≥ 50.6 mg/mL (109.41 mM)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.[1]. BÄumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.
特别提醒公司产品仅供科研使用
