上海一研生物科技有限公司

产品属性：

Cas No.: 22395-22-8

别名: N/A

化学名: N/A

分子式: C16H12O3

分子量: 252.3

溶解度: DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml

储存条件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

7-Methoxyflavone is a flavone that has been found in Z. brasiliensis and has diverse biological activities.1,2,3,4 It inhibits aromatase (IC50 = 1.9 µM in a cell-free assay) and LPS-induced nitric oxide (NO) production by 17.74% in RAW 264.7 macrophages when used at a concentration of 20 µM.1,2 7-Methoxyflavone activates androgen and/or glucocorticoid receptor transcriptional activity in a reporter assay and has antinociceptive effects in the acetic acid-induced writhing test in mice (ED50 = 82.5 µmol/kg).3,41.Ta, N., and Walle, T.Aromatase inhibition by bioavailable methylated flavonesJ. Steroid. Biochem. Mol. Biol.107(1-2)127-129(2007)

2.An, J.-Y., Lee, H.-H., Shin, J.-S., et al.Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cellsBioorg. Med. Chem. Lett.27(11)2613-2616(2017)

3.Nishizaki, Y., Ishimoto, Y., Hotta, Y., et al.Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assayBioorg. Med. Chem. Lett.19(16)4706-4710(2009)

4.da Silva, A.D.S., Cavalcante-Silva, L.H.A., da Matta, C.B.B., et al.Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensisNat. Prod. Res.27(18)1695-1699(2013)
特别提醒公司产品仅供科研使用