上海一研生物科技有限公司

产品属性：

Cas No.: 112111-47-4

别名: N/A

化学名: N/A

分子式: C15H15NO2S

分子量: 273.4

溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.25 mg/ml

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

(S)-Modafinil is the (S) enantiomer of the wakefulness-promoting agent modafinil and an inhibitor of the dopamine transporter (DAT; Ki = 7.64 µM).1,2 It is a less potent DAT inhibitor than (R)-modafinil but is selective for DAT over the serotonin (5-HT) transporter (SERT) and the norepinephrine transporter (NET) at 10 µM.1 (S)-Modafinil (100 and 300 mg/kg, i.p.) elevates extracellular dopamine levels in the mouse nucleus accumbens shell.2 It also increases locomotor activity in mice when administered at a dose of 100 mg/kg and substitutes for cocaine, though less potently, in a drug discrimination test in mice.1,2 (S)-Modafinil is regulated as a Schedule IV compound in the United States. 1.Cao, J., Prisinzano, T.E., Okunola, O.M., et al.SARs at the monoamine transporters for a novel series of modafinil analoguesACS Med. Chem. Lett.2(1)48-52(2010)

2.Loland, C.J., Mereu, M., Okunola, O.M., et al.R-Modafinil (armodafinil): A unique dopamine uptake inhibitor and potential medication for psychostimulant abuseBiol. Psychiatry72(5)405-413(2012)
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