上海一研生物科技有限公司

产品属性：

Cas No.: 22737-96-8

别名: N/A

化学名: N/A

分子式: C20H30O

分子量: 286.5

溶解度: Chloroform: slightly soluble,Methanol: slightly soluble

储存条件: -80°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

11-cis Retinol is an isomer of vitamin A . It is formed from vitamin A, via a trans-retinyl ester intermediate, by the enzyme RPE65 in the retinal pigment epithelium and then converted to 11-cis retinal as part of the visual cycle.1,2 11-cis Retinol is an agonist of salamander and human red rod opsins expressed in COS cells and an inverse agonist of salamander red cone opsin, as well as human red and green cone opsins expressed in COS cells.3 It promotes pigment formation in cone, but not rod, photoreceptors.1.Rando, R.R.The biochemistry of the visual cycleChem. Rev.101(7)1881-1896(2001)

2.Guignard, T.J.P., Jin, M., Pequignot, M.O., et al.FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin: Retinol acyltransferaseJ. Biol. Chem.285(24)18759-18768(2010)

3.Ala-Laurila, P., Cornwall, M.C., Crouch, R.K., et al.The action of 11-cis-retinol on cone opsins and intact cone photoreceptorsJ. Biol. Chem.284(24)16492-16500(2009)
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