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产品属性：
产品名称 | 2-(1,8-Naphthyridin-2-yl)phenol |
规格 | 5 mg、10 mg、25 mg、50 mg |
货号 | EY-01Y14924 |
Cas No.: 65182-56-1
别名: N/A
化学名: N/A
分子式: C14H10N2O
分子量: 222.2
溶解度: DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
2-(1,8-Naphthyridin-2-yl)phenol (2-NP) is an enhancer of STAT1 activity.1 It enhances IFN-γ-induced STAT1-dependent signaling, but not IFN-γ-induced STAT3-dependent signaling or TNF-α-induced NF-κB-dependent signaling in cell-based reporter assays when used at a concentration of 45 µM. 2-NP (45 µM) increases IFN-γ-induced expression of the STAT1 target gene IRF3 and STAT1 phosphorylation in NIH3T3 cells. It increases growth inhibition of MCF-7 and 2fTGH cancer cells induced by IFN-γ at the same concentration. 1.Lynch, R.A., Etchin, J., Battle, T.E., et al.A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-γ in human cancer cellsCancer Res.67(3)1254-1261(2007)
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