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产品属性：
产品名称 | 4-Methylumbelliferyl-α-L-Iduronide (free acid) |
规格 | 500μg、1mg、5mg |
货号 | EY-01Y15261 |
Cas No.: 66966-09-4
别名: N/A
化学名: N/A
分子式: C16H16O9
分子量: 352.3
溶解度: DMF: 20 mg/mL,DMSO: 5 mg/mL,Ethanol: 2 mg/mL,PBS (pH 7.2): 2 mg/mL
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.
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