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产品属性：
产品名称 | 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline |
规格 | 5 mg、10 mg、25 mg |
货号 | EY-01Y15328 |
Cas No.: 77500-04-0
别名: N/A
化学名: N/A
分子式: C11H11N5
分子量: 213.2
溶解度: DMSO: slightly soluble,Methanol: slightly soluble
储存条件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1 It is activated by hydroxylation and subsequent O-acetylation via the cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2 MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.31.Johansson, M.A., and JÄgerstad, M.Occurrence of mutagenic/carcinogenic heterocyclic amines in meat and fish products, including pan residues, prepared under domestic conditionsCarcinogenesis15(8)1511-1518(1994)
2.Metry, K.J., Neale, J.R., Doll, M.A., et al.Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx)Mutat. Res.684(1-2)66-73(2010)
3.Kushida, H., Wakabayashi, K., Sato, H., et al.Dose-response study of MeIQx carcinogenicity in F344 male ratsCancer Lett.83(1-2)31-35(1994)
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