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产品属性：
产品名称 | 1,2,3,4-Tetrahydro-β-carboline |
规格 | 1 g、5 g |
货号 | EY-01Y15571 |
Cas No.: 16502-01-5
别名: N/A
化学名: N/A
分子式: C11H12N2
分子量: 172.2
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.33 mg/ml
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
1,2,3,4-Tetrahydro-β-carboline is a serotonin reuptake inhibitor (IC50 = 7.4 µM in rat brain homogenates) and metabolite of tryptamine .1 In vivo, 1,2,3,4-tetrahydro-β-carboline (20 and 40 µg/animal, i.c.v.) reduces serotonin levels in rat forebrain. It induces serotonin-mediated hyperactivity syndrome (HHS) in rats (ED50 = 48 mg/kg).2 1,2,3,4-Tetrahydro-β-carboline (6.25-75 mg/kg) also reduces acetic acid-induced writhing in rats.3 1.Rommelspacher, H., Bade, P., Coper, H., et al.Inhibition of the reuptake of serotonin by tryptolineNaunyn Schmiedebergs Arch. Pharmacol.292(1)93-95(1976)
2.Pannier, L., and Rommelspacher, H.Actions of tetrahydronorharmane (tetrahydro-β-carboline) on 5-hydroxytryptamine and dopamine mediated mechanismsNeuropharmacology20(1)1-8(1981)
3.Rommelspacher, H., Kauffmann, H., Cohnitz, C.H., et al.Pharmacological properties of tetrahydronorharmane (tryptoline)Naunyn Schmiedebergs Arch. Pharmacol.298(2)83-91(1977)
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