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产品属性：
产品名称 | (+)-SHIN1 |
规格 | 10mM*1mL in DMSO、1mg、5mg、10mg、25mg、50mg、100mg、200mg500mg、 |
货号 | EY-01Y15859 |
Cas No.: N/A
别名: N/A
化学名: N/A
分子式: C24H24N4O2
分子量: 400.47
溶解度: DMSO: ≥ 100 mg/mL (249.71 mM)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
(+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1[1].(+)-SHIN1 ((+)-RZ-2994) is potent against cytosolic SHMT1 with an IC50 for blocking growth of less than 50 nM and 870 nM in SHMT2 deletion cells and HCT-116 cells, respectively[1].[1]. Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.
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