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产品属性：
产品名称 | 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α |
规格 | 1 mg、5 mg、10 mg |
货号 | EY-01Y16083 |
Cas No.: 1194396-71-8
别名: N/A
化学名: N/A
分子式: C31H46N2O8
分子量: 574.7
溶解度: DMSO: 10 mg/ml,Ethanol: 10 mg/ml
储存条件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α (15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α .1 It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α (0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%.1.Impagnatiello, F., Toris, C.B., Batugo, M., et al.Intraocular pressure-lowering activity of NCX 470, a novel nitric oxide-donating bimatoprost in preclinical modelsInvest. Ophthalmol. Vis. Sci.56(11)6558-6564(2015)
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