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产品属性：
产品名称 | (R)-Bicalutamide |
规格 | 10mM*1 mL in DMSO、5 mg、10 mg |
货号 | EY-01Y16133 |
Cas No.: 113299-40-4
别名: N/A
化学名: N/A
分子式: C18H14F4N2O4S
分子量: 430.37
溶解度: DMSO: 100 mg/mL (232.36 mM)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
(R)-Bicalutamide is the (R)-enantiomer of Bicalutamide . (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer[1][2].Bicalutamide is available as a racemic mixture. The R isomer (R-bicalutamide) has an ≈30-fold higher binding affinity to the AR than the S isomer[1].(R)-bicalutamide (0.02-20 μM) reduces naÏve LNCaP cells survival in a dose-dependent[2]. Cell Proliferation Assay[2] Cell Line: LNCaP cells, LNCaP-Rbic cells(R)-Bicalutamide (10 mg/kg; i.g.; daily; for 4 days) has antitumor efficacy in VCaP xenografts mice[3].
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