上海一研生物科技有限公司

产品属性：

Cas No.: 10465-81-3

别名: N/A

化学名: N/A

分子式: C12H20N4O2

分子量: 252.3

溶解度: DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,Ethanol: 1 mg/ml

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

1,1'-(Azodicarbonyl)dipiperidine (ADDP) is a reagent commonly used in the Mitsunobu reaction for the condensation of an alcohol and an acidic compound.1,2 It has been used as a reagent in the synthesis of G protein-coupled receptor 120 (GPR120) agonists with antidiabetic activity and peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ triple agonists.3,41.Tsunoda, T., Yamamiya, Y., and ItÔ, S.1,1′-(Azodicarbonyl)dipiperidine-tributylphosphine, a new reagent system for Mitsunobu reactionTetrahedron Lett.34(10)1639-1642(1993)

2.Hirose, D., Gazvoda, M., Košmrlj, J., et al.Systematic evaluation of 2-arylazocarboxylates and 2-arylazocarboxamides as Mitsunobu reagentsJ. Org. Chem.83(8)4712-4729(2018)

3.Zhang, X., Cai, C., Winters, M., et al.Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonistsBioorg. Med. Chem. Lett.27(15)3272-3278(2017)

4.Mogensen, J.P., Jeppesen, L., Bury, P.S., et al.Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural templateBioorg. Med. Chem. Lett.13(2)257-260(2003)
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