- 产品详情
- 产品参数
- 产品评论
产品属性：
产品名称 | 10-hydroxy Warfarin |
规格 | 500 µg、1 mg |
货号 | EY-01Y16882 |
Cas No.: 83219-99-2
别名: N/A
化学名: N/A
分子式: C19H16O5
分子量: 324.3
溶解度: DMSO: slightly soluble,Methanol: slightly soluble
储存条件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
10-hydroxy Warfarin is a metabolite of (R)-warfarin .1 It is formed from (R)-warfarin by the cytochrome P450 (CYP) isoform CYP3A4. 10-hydroxy Warfarin is an inhibitor of CYP2C9 (IC50 = 1.6 µM), the enzyme that converts (S)-warfarin to its 6-hydroxy warfarin and 7-hydroxy warfarin metabolites.2 1.Kaminsky, L.S., and Zhang, Z.-Y.Human P450 metabolism of warfarinPharmacol. Ther.73(1)67-74(1997)
2.Jones, D.R., Kim, S.-Y., Guderyon, M., et al.Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarinChem. Res. Toxicol.23(5)939-945(2010)
特别提醒公司产品仅供科研使用
