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产品属性：
产品名称 | (Z)-PUGNAc |
规格 | 5mg、10mg |
货号 | EY-01Y17460 |
Cas No.: 132489-69-1
别名: N/A
化学名: [(Z)-[(3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-ylidene]amino] N-phenylcarbamate
分子式: C15H19N3O7
分子量: 353.33
溶解度: 1mg/ml in DMSO， 10mg/mL in DMF
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (Ki = 40-110 nM).[1],[2] It also less potently inhibits other hexosaminidases and exochitinases.[2],[3],[4] (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.[5]
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