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产品属性：
产品名称 | 4-oxo-2-Nonenal-d3 |
规格 | 50 μg、100 μg、500 μg、1 mg |
货号 | EY-01Y17389 |
Cas No.: 1313400-91-7
别名: N/A
化学名: N/A
分子式: C9H11D3O2
分子量: 157.2
溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): .5 mg/ml
储存条件: Store at -80°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
4-oxo-2-Nonenal-d3 (4-ONE-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE by GC- or LC-mass spectrometry (MS). 4-ONE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.1,2 It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.1,2,3 4-ONE is a more recently identified product of lipid peroxidation.4,5,6 It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.7,8 4-ONE also modifies 2'-deoxy guanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.11.Pryor, W.A., and Porter, N.A.Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acidsFree Radical Biology & Medicine8541-543(1990)
2.Esterbauer, H., Schaur, R.J., and Zoliner, H.Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydesFree Radical Biology & Medicine1181-128(1991)
3.Sodum, R.S., and Chung, F.L.1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenalCancer Research48320-323(1988)
4.Rindgen, D., Nakajima, M., Wehrli, S., et al.Covalent modifications to 2'-deoxyguanosine by 4-oxo-nonenal, a novel product of lipid peroxidationChemical Research in Toxicology121195-1204(1999)
5.Lee, S.H., and Blair, I.A.Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidationChemical Research in Toxicology13698-702(2000)
6.Spiteller, P., Kern, W., Reiner, J., et al.Aldehydic lipid peroxidation products derived from linoleic acidBiochimica et Biophysica Acta1531188-208(2001)
7.Liu, Z., Minkler, P.E., and Sayre, L.M.Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenalChemical Research in Toxicology16901-911(2003)
8.Zhang, W.H., Liu, J., Xu, G., et al.Model studies on protein side chain modification by 4-oxo-2-nonenalChemical Research in Toxicology16512-523(2003)
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