上海一研生物科技有限公司

产品属性：

Cas No.: 2349374-37-2

别名: N/A

化学名: N/A

分子式: C22H21ClN2O4

分子量: 412.9

溶解度: DMSO: soluble,Methanol: slightly soluble

储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：

9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF-•B activity in RAW-Blue• cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.|1. Guo, H., Verhoek, I.C., Prins, G.G.H., et al. Novel 15-lipoxygenase-1 inhibitor protects macrophages from lipopolysaccharide-induced cytotoxicity. J. Med. Chem. 62(9), 4624-4637 (2019).
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