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产品属性：
产品名称 | 6H05 (TFA) |
规格 | 10mM*1 mL in DMSO、2mg、5mg、10mg |
货号 | EY-01Y17719 |
Cas No.: 2061344-88-3
别名: N/A
化学名: N/A
分子式: C22H31ClF3N3O4S3
分子量: 590.14
溶解度: DMSO: ≥ 51 mg/mL (86.42 mM)
储存条件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51.
[2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.
特别提醒公司产品仅供科研使用
